Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir.
نویسندگان
چکیده
Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.
منابع مشابه
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 39 5 شماره
صفحات -
تاریخ انتشار 1995